Helps dissolve other soluble ingredients. Helps the mechanical process of cleaning teeth in mouthwashes.
Bromelain is a group of enzymes found in the fruit and stem of the pineapple plant. Pineapple is native to the Americas but is now grown throughout the world in tropical and subtropical regions. Historically, natives of Central and South America used pineapple for a variety of ailments, such as digestive disorders.
Bromelain is promoted as a dietary supplement for reducing pain and swelling, especially of the nose and sinuses, gums, and other body parts after surgery or injury. It is also promoted for osteoarthritis, cancer, digestive problems, and muscle soreness. Topical bromelain is promoted for burns.
Few side effects of bromelain have been reported in studies. The most commonly reported side effects have been stomach upset and diarrhea.
Allergic reactions may occur in individuals who are sensitive or allergic to pineapples or who have other allergies.
Little is known about whether it’s safe to use bromelain during pregnancy or while breastfeeding.
Bromelain may interact with some medicines, such as the antibiotic amoxicillin. If you take medicines, talk to your health care provider before taking bromelain.
It is thought that calcium glycerophosphate may act through a variety of mechanisms to produce an anti-caries effect , These include increasing acid-resistance of the enamel, increasing enamel mineralization, modifying plaque, acting as a pH-buffer in plaque, and elevating Calcium and phosphate levels. When used as an electrolyte replacement, calcium glycerophosphate donates Calcium and inorganic phosphate. Calcium glycerophosphate is preferable to calcium phosphate due to its increased solubility. Compared to combination calcium gluconate and potassium phosphate, calcium glycerophosphate produces greater phosphate retention which allows for increased Calcium retention and ultimately greater incorporation of the ions into bone structure
By FDA, calcium glycerophosphate is considered a generally recognized as safe (GRAS) food ingredient as a nutrient supplement (source of calcium or phosphorus), or in food products such as gelatins, puddings, and fillings. It is also present in dental or oral hygiene products due to its cariostatic effects.
Chloride Magnesium known by chemical formula MgCl2, is a type of salt used as a nutritional supplement. It is found naturally in seawater but is most readily harvested from the brine of salt lakes—such as the Great Salt Lake in northern Utah and the Dead Sea situated between Jordan and Israel—where the salt content may be as high as 50%. Magnesium chloride is thought to improve health, in part by increasing magnesium levels in people with a known deficiency ,also it is used as toothpaste ingredient to prevent bad breath,remove plaque,purify the mouth,prevent ingie teeth,whiten the teeth and for reconstruction of the enamel
Magnesium chloride supplements are considered safe if used as directed. Common side effects ,that are considered during injectiion or internal usage , are stomach upset, nausea, diarrhea, and vomiting . Many of these side effects can be alleviated by taking the supplement with food. Nearly all forms of magnesium supplements have a laxative effect.
Glycerol (also called glycerine or glycerin) is a simple polyol compound. Glycerin is mildly antimicrobial and antiviral and is an FDA approved treatment for wounds. The Red Cross reports that an 85% solution of glycerin shows bactericidal and antiviral effects, and wounds treated with glycerin show reduced inflammation after roughly 2 hours. Due to this it is used widely in wound care products, including glycerin based hydrogel sheets for burns and other wound care. It is approved for all types of wound care except third degree burns, and is used to package donor skin used in skin grafts. There is no topical treatment approved for third degree burns, and so this limitation is not exclusive to glycerin. Glycerol is used in medical, pharmaceutical and personal care preparations, often as a means of improving smoothness, providing lubrication, and as a humectant. In toothpastes Glycerol holds onto water and prevents the toothpaste from drying out in the tube, and also prevents dryness in the mouth during brushing. It can help reduce bacterial activity by reducing the available water activity and therefore has a protective action against tooth decay. Glycerin does not damage gums or tooth enamel.
Glycerin as ingredient of foods,cosmetic products ,toothpaste and ...may cause : Upset stomach, Stomach cramps, Gas, Diarrhea, Burning, Rectal irritation. Glycerin does not damage gums or tooth enamel.
Skin Cancer: Applying personal care product containing parabens—especially methylparaben—can lead to UV-induced damage of skin cells and disruption of cell proliferation (cell growth rate). Daily application, in particular, can lead to increased concentrations of methylparaben because it is not completely metabolized.
Generally, parabens don't irritate the skin or cause allergy. Other research indicates that parabens are safe as used in cosmetics and preferred since they are gentle, non-sensitizing, and highly effective.
A number of commonly used parabens have had the U.S. Food and Drug Administration’s (FDA) Generally Recognized as Safe (GRAS) classification since the early 1970s. The GRAS designation means the substance is generally recognized, among qualified experts, as having been adequately shown to be safe under the conditions of its intended use. Other examples of compounds that are considered GRAS include vitamin A, wheat starch and sugar. FDA also participates on the Cosmetic Ingredient Review (CIR), an independent panel of medical and scientific experts that meets quarterly to assess the safety of cosmetic ingredients based on data in the published literature, as well as data voluntarily provided by the cosmetics industry. FDA takes the results of CIR reviews into consideration when conducting a safety assessment.
In 1984, CIR reviewed the safety of parabens used in cosmetics and concluded that they were safe, even in extremely large doses. Typically parabens are used at levels ranging from 0.01 to 0.3 percent, and the CIR concluded they were safe for use in cosmetics at levels up to 25 percent.
In 2012, the CIR reopened its safety report on parabens to consider all new data. As it did in 1984, the expert panel reaffirmed the safety of cosmetic products in which parabens preservatives are used.
The takeaway. Silicon dioxide exists naturally within the earth and our bodies. There isn't yet evidence to suggest it's dangerous to ingest as a food additive, but more research is needed on what role it plays in the body. Chronic inhalation of silica dust can lead to lung disease.
The Food and Drug Administration (FDA) regards SLS as safe as a food additive. Regarding its use in cosmetics and body products, the safety assessment study of SLS, published in 1983 in the International Journal of Toxicology (the most recent assessment), found that it’s not harmful if used briefly and rinsed from the skin, as with shampoos and soaps. The report says that products that stay on the skin longer shouldn’t exceed 1 percent concentration of SLS. However, the same assessment did suggest some possible, albeit minimal, risk to humans using SLS. For example, some tests found that continuous skin exposure to SLS could cause mild to moderate irritation in animals. Nevertheless, the assessment concluded that SLS is safe in formulations used in cosmetics and personal care products. Because many of these products are designed to be rinsed off after short applications, the risks are minimal. According to most research, SLS is an irritant but not a carcinogen. Studies have shown no link between the use of SLS and increased cancer risk. According to a 2015 study, SLS is safe for use in household cleaning products.
In the 1970s, studies performed on laboratory rats found an association between consumption of high doses of saccharin and the development of bladder cancer. However, further study determined that this effect was due to a mechanism that is not relevant to humans.Epidemiological studies have shown no evidence that saccharin is associated with bladder cancer in humans.The International Agency for Research on Cancer (IARC) originally classified saccharin in Group 2B ("possibly carcinogenic to humans") based on the rat studies, but downgraded it to Group 3 ("not classifiable as to the carcinogenicity to humans") upon review of the subsequent research. Saccharin has no food energy and no nutritional value. It is safe to consume for individuals with diabetes. People with sulfonamide allergies can experience allergic reactions to saccharin, as it is a sulfonamide derivative and can cross-react. Saccharin in toothpaste can cause burning sensations, swelling, and rashes of the mouth and lips in sensitive individuals.
Main Routes of Exposure: Inhalation; skin contact; eye contact. Inhalation: At high concentrations: can irritate the nose and throat.
Skin Contact: May cause mild irritation.
Eye Contact: May cause slight irritation as a "foreign object". Tearing, blinking and mild temporary pain may occur as particles are rinsed from the eye by tears.
Ingestion: Not harmful.
Effects of Long-Term (Chronic) Exposure: Conclusions cannot be drawn from the limited studies available.
Carcinogenicity: Possible carcinogen. May cause cancer based on animal information. Has been associated with: lung cancer.
Although tocopheryrl acetate is thought to be relatively safe, there are some potential risks, particularly if the recommended dosage is exceeded—the recommended dietary allowance is 15 milligrams (mg) or 22.4 internal units (IU). In fact, taking too much vitamin E could lead to toxicity.5
Because vitamin E is fat soluble, the body cannot get rid of excessive amounts in the urine. Some studies have shown an increase in mortality rate among people taking large doses of vitamin E, especially in people with multiple medical problems. Other possible side effects include breast tenderness, gonadal dysfunction, abdominal pain, blood pressure elevation, or diarrhea.
According to the Memorial Slone Kettering Cancer Center, symptoms of vitamin E toxicity from long-term use of more than 400–800 IU per day may include:
- Blurred vision
- Thrombophlebitis (an inflammation of the vein due to a blood clot)
Vitamin E supplements may also increase the risk of having a stroke. The reason tocopheryl acetate may increase the risk of a stroke is due to its anti-blood-clotting side effects.
Skin care products with tocopheryl acetate may cause a local skin reaction. Symptoms of an allergic reaction of the skin include reddening or a rash in the area that the cream or ointment was applied.
For most people, eating foods that contain xanthan gum appears to be completely safe. While many foods contain it, it only makes up about 0.05–0.3% of a food product. Moreover, a typical person consumes less than 1 gram of xanthan gum per day. Amounts 20 times that have been proven to be safe. In fact, the Joint Expert Committee on Food Additives assigned it an acceptable daily intake of “not specified.” It gives this designation when food additives have a very low toxicity, and levels in foods are so small that they do not pose a health hazard. But people should avoid inhaling xanthan gum. Workers who handled it in powder form were found to have flu-like symptoms and nose and throat irritation.
So even though you may eat many foods containing it, your intake is so small that you’re unlikely to experience either benefits or negative side effects.
Xylitol is generally well tolerated, but some people experience digestive side effects when they consume too much. The sugar alcohols can pull water into your intestine or get fermented by gut bacteria. This can lead to gas, bloating and diarrhea.