Helps dissolve other soluble ingredients. Helps the mechanical process of cleaning teeth in mouthwashes.
A chemical compound which adds odours to dental products
Sodium carboxymethylcellulose is generally recognized as safe (GRAS) when used in accordance with good manufacturing practice in food for human consumption.
Eugenolis listed by the FDA as GRAS when consumed orally, in unburned form. It is nontoxic in food but toxic upon inhalation. High doses of may cause damage to the liver (Thompson et al., 1998).
Fluoride-containing compounds, such as sodium fluoride or sodium monofluorophosphate are used in topical and systemic fluoride therapy for preventing tooth decay. They are used for water fluoridation and in many products associated with oral hygiene. Originally, sodium fluoride was used to fluoridate water; hexafluorosilicic acid (H2SiF6) and its salt sodium hexafluorosilicate (Na2SiF6) are more commonly used additives, especially in the United States. The fluoridation of water is known to prevent tooth decayand is considered by the U.S. Centers for Disease Control and Prevention as "one of 10 great public health achievements of the 20th century". In some countries where large, centralized water systems are uncommon, fluoride is delivered to the populace by fluoridating table salt. For the method of action for cavity prevention, see Fluoride therapy. Fluoridation of water has its critics (see Water fluoridation controversy).
Fluoride toxicity is a condition in which there are elevated levels of the fluoride ion in the body. Although fluoride is safe for dental health at low concentrations, sustained consumption of large amounts of soluble fluoride salts is dangerous. Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride/kg body weight). Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg or 10 to 15 mg for a 50 kg person) than lethal doses. Although it is helpful topically for dental health in low dosage, chronic ingestion of fluoride in large amounts interferes with bone formation. In this way, the most widespread examples of fluoride poisoning arise from consumption of ground water that is abnormally fluoride-rich.
Hydrated silica is listed by the US Food and Drug Administration as "Generally Recognized as Safe", however one drawback of abrasives in toothpaste is that they may make some people's teeth sensitive, especially if they brush very hard and do not brush with a soft-bristled toothbrush. The dentin and the pulp that lie beneath the enamel are sensitive, says the American Dental Association (ADA), so that why it's key to have a strong enamel.
Contact causes severe burns with redness, swelling, pain and blurred vision. Permanent damage including blindness can result. Ingestion: Can burn the lips, tongue, throat and stomach. Symptoms may include nausea, vomiting, stomach cramps and diarrhea.
The Food and Drug Administration (FDA) regards SLS as safe as a food additive. Regarding its use in cosmetics and body products, the safety assessment study of SLS, published in 1983 in the International Journal of Toxicology (the most recent assessment), found that it’s not harmful if used briefly and rinsed from the skin, as with shampoos and soaps. The report says that products that stay on the skin longer shouldn’t exceed 1 percent concentration of SLS. However, the same assessment did suggest some possible, albeit minimal, risk to humans using SLS. For example, some tests found that continuous skin exposure to SLS could cause mild to moderate irritation in animals. Nevertheless, the assessment concluded that SLS is safe in formulations used in cosmetics and personal care products. Because many of these products are designed to be rinsed off after short applications, the risks are minimal. According to most research, SLS is an irritant but not a carcinogen. Studies have shown no link between the use of SLS and increased cancer risk. According to a 2015 study, SLS is safe for use in household cleaning products.
In the 1970s, studies performed on laboratory rats found an association between consumption of high doses of saccharin and the development of bladder cancer. However, further study determined that this effect was due to a mechanism that is not relevant to humans.Epidemiological studies have shown no evidence that saccharin is associated with bladder cancer in humans.The International Agency for Research on Cancer (IARC) originally classified saccharin in Group 2B ("possibly carcinogenic to humans") based on the rat studies, but downgraded it to Group 3 ("not classifiable as to the carcinogenicity to humans") upon review of the subsequent research. Saccharin has no food energy and no nutritional value. It is safe to consume for individuals with diabetes. People with sulfonamide allergies can experience allergic reactions to saccharin, as it is a sulfonamide derivative and can cross-react. Saccharin in toothpaste can cause burning sensations, swelling, and rashes of the mouth and lips in sensitive individuals.
Main Routes of Exposure: Inhalation; skin contact; eye contact. Inhalation: At high concentrations: can irritate the nose and throat.
Skin Contact: May cause mild irritation.
Eye Contact: May cause slight irritation as a "foreign object". Tearing, blinking and mild temporary pain may occur as particles are rinsed from the eye by tears.
Ingestion: Not harmful.
Effects of Long-Term (Chronic) Exposure: Conclusions cannot be drawn from the limited studies available.
Carcinogenicity: Possible carcinogen. May cause cancer based on animal information. Has been associated with: lung cancer.
Regulatory bodies in different countries have different opinions about the safety of yellow 5. Following the release of a groundbreaking 2007 study linking AFCs to hyperactivity in preschool and school-aged children, the Food Standards Agency of the European Union (EU) deemed six AFCs unsafe for kids.