Fluoride-containing compounds, such as sodium fluoride or sodium monofluorophosphate are used in topical and systemic fluoride therapy for preventing tooth decay. They are used for water fluoridation and in many products associated with oral hygiene. Originally, sodium fluoride was used to fluoridate water; hexafluorosilicic acid (H2SiF6) and its salt sodium hexafluorosilicate (Na2SiF6) are more commonly used additives, especially in the United States. The fluoridation of water is known to prevent tooth decayand is considered by the U.S. Centers for Disease Control and Prevention as "one of 10 great public health achievements of the 20th century". In some countries where large, centralized water systems are uncommon, fluoride is delivered to the populace by fluoridating table salt. For the method of action for cavity prevention, see Fluoride therapy. Fluoridation of water has its critics (see Water fluoridation controversy).
Fluoride toxicity is a condition in which there are elevated levels of the fluoride ion in the body. Although fluoride is safe for dental health at low concentrations, sustained consumption of large amounts of soluble fluoride salts is dangerous. Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride/kg body weight). Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg or 10 to 15 mg for a 50 kg person) than lethal doses. Although it is helpful topically for dental health in low dosage, chronic ingestion of fluoride in large amounts interferes with bone formation. In this way, the most widespread examples of fluoride poisoning arise from consumption of ground water that is abnormally fluoride-rich.
Glycerol (also called glycerine or glycerin) is a simple polyol compound. Glycerin is mildly antimicrobial and antiviral and is an FDA approved treatment for wounds. The Red Cross reports that an 85% solution of glycerin shows bactericidal and antiviral effects, and wounds treated with glycerin show reduced inflammation after roughly 2 hours. Due to this it is used widely in wound care products, including glycerin based hydrogel sheets for burns and other wound care. It is approved for all types of wound care except third degree burns, and is used to package donor skin used in skin grafts. There is no topical treatment approved for third degree burns, and so this limitation is not exclusive to glycerin. Glycerol is used in medical, pharmaceutical and personal care preparations, often as a means of improving smoothness, providing lubrication, and as a humectant. In toothpastes Glycerol holds onto water and prevents the toothpaste from drying out in the tube, and also prevents dryness in the mouth during brushing. It can help reduce bacterial activity by reducing the available water activity and therefore has a protective action against tooth decay. Glycerin does not damage gums or tooth enamel.
Glycerin as ingredient of foods,cosmetic products ,toothpaste and ...may cause : Upset stomach, Stomach cramps, Gas, Diarrhea, Burning, Rectal irritation. Glycerin does not damage gums or tooth enamel.
Hydrated silica is listed by the US Food and Drug Administration as "Generally Recognized as Safe", however one drawback of abrasives in toothpaste is that they may make some people's teeth sensitive, especially if they brush very hard and do not brush with a soft-bristled toothbrush. The dentin and the pulp that lie beneath the enamel are sensitive, says the American Dental Association (ADA), so that why it's key to have a strong enamel.
The Cosmetics Database found PEG 8 Laurate to be a moderate to high hazard, in part because of its inclusion of Lauric Acid. It notes the organ toxicity and contamination concerns associated with all PEGs, and also allergies and immunotoxicity concerns associated with its rating of Lauric Acid. According to a study published in the International Journal of Toxicology, PEGs (including PEG 8 Laurate) can contain harmful impurities, including: Ethylene Oxide, known to increase the incidences of uterine and breast cancers and of leukemia and brain cancer, according to experimental results reported by the National Toxicology Program; 1,4-dioxane, a known carcinogen; PAHs, known to increase the risk of breast cancer; lead; iron; and arsenic (Source). Products and formulas containing PEGs should not be used on broken or irritated skin. Although PEGs are considered safe for use topically on healthy skin, studies showed that patients suffering from severe burns were treated with PEG-based antimicrobial cream; this treatment resulted in kidney toxicity. "The PEG content of the antimicrobial cream was determined to be the causative agent. However, no evidence of systemic toxicity occurred in studies with intact skin. Because of the observation of kidney effects in burn patients, the CIR Expert Panel qualified their conclusion on the safety of the PEG ingredients to state that cosmetic formulations containing these ingredients should not be used on damaged skin" (CosmeticsInfo.org).
Common side effects of sodium_bicarbonate include: Aggravated congestive heart failure (CHF)
High blood sodium levels
Low blood calcium levels
Low blood potassium levels
Muscle spasms (associated with low calcium levels)
Excess fluid in the lungs (pulmonary edema)
The Cosmetics Database only notes data gaps and no negative side effects or warnings regarding the use of Sodium Methyl Cocoyl Taurate in cosmetics or personal care products. No definitive studies or warnings could be found elsewhere, although Health-Report.co.uk and another site both listed it as a synthetic toxin, with no explanation as to its toxic properties.
For most people, eating foods that contain xanthan gum appears to be completely safe. While many foods contain it, it only makes up about 0.05–0.3% of a food product. Moreover, a typical person consumes less than 1 gram of xanthan gum per day. Amounts 20 times that have been proven to be safe. In fact, the Joint Expert Committee on Food Additives assigned it an acceptable daily intake of “not specified.” It gives this designation when food additives have a very low toxicity, and levels in foods are so small that they do not pose a health hazard. But people should avoid inhaling xanthan gum. Workers who handled it in powder form were found to have flu-like symptoms and nose and throat irritation.
So even though you may eat many foods containing it, your intake is so small that you’re unlikely to experience either benefits or negative side effects.